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http://www.nature.com/articles/gim2017238.epdf?author_access_token=MSLRPoDrzurFdQf6owGd2NRgN0jAjWel9jnR3ZoTv0NJJRjquyVXbAfO0eqa6nplg7ZIJPBiFqGVK6keMtr4BkfN5k1RBJQtYP4LQtinY41g9KQ4tY2cznyevrQ5FSom