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http://www.nature.com/articles/gim2017211.epdf?author_access_token=phJWvXl8_sjkPPmEAhPpjNRgN0jAjWel9jnR3ZoTv0MpJulcfP_luVKdyNQzxlcfkYQrcABXvROuHKY2JPjpBKm0ptVGUFVUyV449x3N2o9xYYwnAzOdBvszg9vxD7UX