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https://www.nature.com/articles/s41436-018-0028-2.epdf?author_access_token=r_wlq_pcfzGy7FfEDm5DwNRgN0jAjWel9jnR3ZoTv0OO6--LNuw-Kuq1PgbdKd8IAilDjlEuMU4xcxuhMQFBxA6WBRN-VemTAxwBkyxs92HKfXN9OOb-qjOSgnzNXpqcS1-_Hra08Th7wXJhT2f6Pg==