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https://www.nature.com/articles/s41436-018-0118-1.epdf?author_access_token=0d0EaW4KW5sxFJbGw9kT7dRgN0jAjWel9jnR3ZoTv0PnWSQY0kPteenG0E8XZVnLetGWZysOHEoU66_o45kxJ5Yvzjc4G0L8WD8sp5B9TVbEuAZsTfBIDCr0dZ0A9nfB2aJWqn7cClZiGquBU2vbAA==